Dync2h1 - dynein cytoplasmic 2 heavy chain 1

Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Acts upstream of or within several processes, including animal organ development; cilium organization; and positive regulation of smoothened signaling pathway. Located in apical part of cell; axoneme; and motile cilium. Is expressed in brain ventricular layer and olfactory epithelium. Used to study VACTERL association and asphyxiating thoracic dystrophy 3. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy 3. Orthologous to human DYNC2H1 (dynein cytoplasmic 2 heavy chain 1). [provided by Alliance of Genome Resources, Apr 2022]