Raf1 - v-raf-leukemia viral oncogene 1

Enables small GTPase binding activity. Acts upstream of or within several processes, including cell surface receptor signaling pathway; gland development; and positive regulation of nitrogen compound metabolic process. Located in pseudopodium. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and immune system. Used to study Noonan syndrome 5. Human ortholog(s) of this gene implicated in Noonan syndrome (multiple); Noonan syndrome with multiple lentigines 2; adenocarcinoma (multiple); and dilated cardiomyopathy 1NN. Orthologous to human RAF1 (Raf-1 proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]