Dnah1 - dynein, axonemal, heavy chain 1

Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Acts upstream of or within epithelial cilium movement involved in extracellular fluid movement and flagellated sperm motility. Located in sperm flagellum. Is expressed in cerebellum; choroid plexus; and lateral ventricle choroid plexus. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 37 and spermatogenic failure 18. Orthologous to human DNAH1 (dynein axonemal heavy chain 1). [provided by Alliance of Genome Resources, Apr 2022]