Orai1 - ORAI calcium release-activated calcium modulator 1

Predicted to enable identical protein binding activity and store-operated calcium channel activity. Acts upstream of or within calcium ion import; mammary gland epithelium development; and store-operated calcium entry. Located in basolateral plasma membrane. Part of protein-containing complex. Is expressed in several structures, including alimentary system; brain; reproductive system; respiratory system; and skin. Human ortholog(s) of this gene implicated in immunodeficiency 9 and tubular aggregate myopathy 2. Orthologous to human ORAI1 (ORAI calcium release-activated calcium modulator 1). [provided by Alliance of Genome Resources, Apr 2022]