Irak2 - interleukin-1 receptor-associated kinase 2

Predicted to enable protein heterodimerization activity; protein homodimerization activity; and protein serine/threonine kinase activity. Acts upstream of or within lipopolysaccharide-mediated signaling pathway; negative regulation of DNA-binding transcription factor activity; and positive regulation of NF-kappaB transcription factor activity. Predicted to be active in cytoplasm; nucleus; and plasma membrane. Is expressed in several structures, including Peyer's patch; brain; genitourinary system; respiratory system; and thymus. Orthologous to human IRAK2 (interleukin 1 receptor associated kinase 2). [provided by Alliance of Genome Resources, Apr 2022]