Osr2 - odd-skipped related 2

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ development; embryonic limb morphogenesis; and positive regulation of macromolecule metabolic process. Acts upstream of or within several processes, including embryonic skeletal system morphogenesis; kidney development; and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including branchial arch; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human OSR2 (odd-skipped related transciption factor 2). [provided by Alliance of Genome Resources, Apr 2022]