Ovol2 - ovo like zinc finger 2

Enables DNA binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and chromatin binding activity. Involved in several processes, including negative regulation of epithelial to mesenchymal transition; regulation of SMAD protein signal transduction; and regulation of gene expression. Acts upstream of or within several processes, including circulatory system development; embryonic morphogenesis; and regulation of transcription, DNA-templated. Located in nucleus. Is expressed in several structures, including early conceptus; genitourinary system; gut; head surface ectoderm; and otocyst. Human ortholog(s) of this gene implicated in posterior polymorphous corneal dystrophy 1. Orthologous to human OVOL2 (ovo like zinc finger 2). [provided by Alliance of Genome Resources, Apr 2022]