Lgr4 - leucine-rich repeat-containing G protein-coupled receptor 4

Enables transmembrane signaling receptor activity. Involved in several processes, including metanephros development; regulation of gene expression; and regulation of signal transduction. Acts upstream of or within several processes, including epithelial cell proliferation involved in renal tubule morphogenesis; intestinal stem cell homeostasis; and male genitalia development. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; eye; metanephros; nasal process; and testis. Used to study glaucoma. Human ortholog(s) of this gene implicated in osteoporosis. Orthologous to human LGR4 (leucine rich repeat containing G protein-coupled receptor 4). [provided by Alliance of Genome Resources, Apr 2022]