Eprs1 - glutamyl-prolyl-tRNA synthetase

Enables proline-tRNA ligase activity. Involved in several processes, including cellular response to insulin stimulus; prolyl-tRNA aminoacylation; and regulation of long-chain fatty acid import into cell. Acts upstream of or within cellular response to interferon-gamma. Located in plasma membrane. Part of GAIT complex and aminoacyl-tRNA synthetase multienzyme complex. Is expressed in several structures, including alimentary system; axial skeleton; craniocervical region bone; face; and liver. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy. Orthologous to human EPRS1 (glutamyl-prolyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]