Ticam1 - TIR domain containing adaptor molecule 1

Predicted to enable protein kinase binding activity. Involved in several processes, including TRIF-dependent toll-like receptor signaling pathway; cellular response to oxidised low-density lipoprotein particle stimulus; and positive regulation of cytokine production. Acts upstream of or within several processes, including positive regulation of cytokine production; positive regulation of lymphocyte activation; and positive regulation of nitrogen compound metabolic process. Located in cytosol and mitochondrion. Is expressed in genitourinary system. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human TICAM1 (toll like receptor adaptor molecule 1). [provided by Alliance of Genome Resources, Apr 2022]