Prickle1 - prickle planar cell polarity protein 1

Predicted to enable zinc ion binding activity. Acts upstream of or within aorta development and coronary vasculature development. Located in nucleus. Is expressed in several structures, including brain; embryo mesenchyme; genitourinary system; limb; and sensory organ. Used to study autosomal recessive Robinow syndrome and velocardiofacial syndrome. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy 1B. Orthologous to human PRICKLE1 (prickle planar cell polarity protein 1). [provided by Alliance of Genome Resources, Apr 2022]