Ppif - peptidylprolyl isomerase F (cyclophilin F)

Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Involved in several processes, including negative regulation of ATPase activity; positive regulation of release of cytochrome c from mitochondria; and regulation of proton transport. Acts upstream of or within apoptotic mitochondrial changes; necroptotic process; and response to oxidative stress. Located in mitochondrion. Part of mitochondrial permeability transition pore complex. Is expressed in lower jaw tooth and tooth. Orthologous to human PPIF (peptidylprolyl isomerase F). [provided by Alliance of Genome Resources, Apr 2022]