Gas8 - growth arrest specific 8

Enables microtubule binding activity and small GTPase binding activity. Involved in positive regulation of protein localization to cilium; positive regulation of smoothened signaling pathway; and regulation of microtubule binding activity. Acts upstream of or within several processes, including axoneme assembly; epithelial cilium movement involved in extracellular fluid movement; and flagellated sperm motility. Located in Golgi apparatus; ciliary basal body; and sperm flagellum. Is expressed in bronchus; nasal cavity epithelium; and nervous system. Used to study primary ciliary dyskinesia 33. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 33. Orthologous to human GAS8 (growth arrest specific 8). [provided by Alliance of Genome Resources, Apr 2022]