Gck - glucokinase

Enables glucokinase activity. Involved in calcium ion import; cellular glucose homeostasis; and positive regulation of insulin secretion. Acts upstream of or within several processes, including carbohydrate phosphorylation; glucose homeostasis; and regulation of insulin secretion. Located in cytosol; mitochondrion; and nucleus. Is expressed in several structures, including alimentary system; brain; musculoskeletal system; reproductive system; and sensory organ. Used to study familial hyperinsulinemic hypoglycemia 3; hyperinsulinemic hypoglycemia; maturity-onset diabetes of the young type 2; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in artery disease (multiple); familial hyperinsulinemic hypoglycemia 3; and glucose metabolism disease (multiple). Orthologous to human GCK (glucokinase). [provided by Alliance of Genome Resources, Apr 2022]