Enables ubiquitin-protein transferase activity. Contributes to ubiquitin protein ligase activity. Involved in several processes, including cellular protein metabolic process; negative regulation of NIK/NF-kappaB signaling; and positive regulation of circadian rhythm. Located in cytosol and nucleus. Part of SCF ubiquitin ligase complex. Is expressed in cap mesenchyme; early tubule; ovary; and testis. Orthologous to human FBXW11 (F-box and WD repeat domain containing 11). [provided by Alliance of Genome Resources, Apr 2022]