Klhl3 - kelch-like 3

Predicted to enable cullin family protein binding activity. Predicted to be involved in several processes, including cellular protein metabolic process; distal tubule morphogenesis; and renal sodium ion absorption. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytosol. Is expressed in endocrine gland; genitourinary system; heart; lung; and nervous system. Used to study pseudohypoaldosteronism. Human ortholog(s) of this gene implicated in pseudohypoaldosteronism. Orthologous to human KLHL3 (kelch like family member 3). [provided by Alliance of Genome Resources, Apr 2022]