Trex1 - three prime repair exonuclease 1

Predicted to enable several functions, including DNA binding activity; WW domain binding activity; and mismatch repair complex binding activity. Predicted to be involved in DNA catabolic process, exonucleolytic. Predicted to act upstream of or within several processes, including DNA metabolic process; cellular response to cytokine stimulus; and regulation of generation of precursor metabolites and energy. Predicted to be located in cytosol; endoplasmic reticulum; and nuclear replication fork. Predicted to be part of oligosaccharyltransferase complex and protein-DNA complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome; Chilblain lupus; retinal vasculopathy with cerebral leukodystrophy; and systemic lupus erythematosus. Orthologous to human TREX1 (three prime repair exonuclease 1). [provided by Alliance of Genome Resources, Apr 2022]