Waterhouse-Friderichsen Syndrome, also known as acute adrenal insufficiency with meningococcal septicaemia, is related to premature ovarian failure 7 and purpura fulminans. An important gene associated with Waterhouse-Friderichsen Syndrome is POMC (Proopiomelanocortin), and among its related pathways/superpathways are G alpha (s) signalling events and Heparin-induced Thrombocytopenia Pathway, Adverse Drug Reaction. Affiliated tissues include adrenal gland and spleen, and related phenotype is homeostasis/metabolism.