Whipple Disease

Whipple Disease, also known as intestinal lipodystrophy, is related to aortic valve insufficiency and olecranon bursitis. An important gene associated with Whipple Disease is IRF4 (Interferon Regulatory Factor 4), and among its related pathways/superpathways are Hematopoietic Stem Cells and Lineage-specific Markers and IL27-mediated signaling events. Affiliated tissues include heart and brain, and related phenotypes are depression and developmental regression