Vitamin K Deficiency Bleeding, also known as vitamin k deficiency, is related to vitamin k-dependent clotting factors, combined deficiency of, 2 and vitamin k-dependent clotting factors, combined deficiency of, 1. An important gene associated with Vitamin K Deficiency Bleeding is F2 (Coagulation Factor II, Thrombin), and among its related pathways/superpathways are Metabolism of proteins and Response to elevated platelet cytosolic Ca2+. The drugs Apixaban and Fluindione have been mentioned in the context of this disorder. Affiliated tissues include bone and liver, and related phenotypes are homeostasis/metabolism and cardiovascular system