Variola Major

Variola Major, also known as smallpox, is related to variola minor and smallpox, and has symptoms including exanthema, fever and pruritus. An important gene associated with Variola Major is DUSP14 (Dual Specificity Phosphatase 14), and among its related pathways/superpathways are Nuclear Events (kinase and transcription factor activation) and Signal transduction_Erk Interactions- Inhibition of Erk. The drugs Calcium acetate and Sevelamer have been mentioned in the context of this disorder. Affiliated tissues include skin, and related phenotype is Increased apoptosis.