Venous Insufficiency, also known as peripheral venous insufficiency, is related to chronic venous insufficiency and post-thrombotic syndrome. An important gene associated with Venous Insufficiency is PLAT (Plasminogen Activator, Tissue Type), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. The drugs Racepinephrine and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include skin and endothelial, and related phenotypes are homeostasis/metabolism and nervous system