Vaccinia is related to viral infectious disease and herpes simplex, and has symptoms including rash, fever and body aches. An important gene associated with Vaccinia is VRK1 (VRK Serine/Threonine Kinase 1), and among its related pathways/superpathways are Signal Transduction and Innate Immune System. The drugs Smallpox and monkeypox vaccine modified vaccinia ankara-bavarian nordic and Sorafenib have been mentioned in the context of this disorder. Affiliated tissues include skin and t cells, and related phenotypes are homeostasis/metabolism and immune system