Ulcer of Lower Limbs, also known as ulcer of heel and midfoot, is related to peripheral vascular disease and dental pulp necrosis. An important gene associated with Ulcer of Lower Limbs is RCAN1 (Regulator Of Calcineurin 1), and among its related pathways/superpathways are Apoptotic Pathways in Synovial Fibroblasts and TGF-Beta Pathway. Affiliated tissues include skin and endothelial, and related phenotypes are homeostasis/metabolism and neoplasm