Type 1 Diabetes Mellitus 12, also known as diabetes mellitus, insulin-dependent, 12, is related to graves disease 1 and autoimmune thyroid disease 3. An important gene associated with Type 1 Diabetes Mellitus 12 is CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4), and among its related pathways/superpathways are CD28 Signaling in T-Helper Cell and Peptide hormone metabolism. Affiliated tissues include thyroid, and related phenotypes are endocrine/exocrine gland and immune system