Tylosis with Esophageal Cancer, also known as palmoplantar keratoderma-esophageal carcinoma syndrome, is related to neuroendocrine tumor and esophageal cancer. An important gene associated with Tylosis with Esophageal Cancer is RHBDF2 (Rhomboid 5 Homolog 2). Affiliated tissues include skin and breast, and related phenotypes are nausea and vomiting and palmoplantar keratoderma