Toxic Shock Syndrome (TSS)

Toxic Shock Syndrome, also known as septic shock, is related to critical covid-19 and melioidosis, and has symptoms including fever, rash and hypotension. An important gene associated with Toxic Shock Syndrome is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Simvastatin and Milrinone have been mentioned in the context of this disorder. Affiliated tissues include kidney and skin, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and homeostasis/metabolism