Tetralogy of Fallot (TOF)

Alias:
Ventricular Septal Defect with Pulmonary Stenosis or Atresia, Dextraposition of Aorta, and Hypertrophy of Right Ventricle
Fallot Tetralogy
Tof
Interventricular Septal Defect with Dextroposition of Aorta, Pulmonary Stenosis and Hypertrophy of Right Ventricle
Pulmonary Atresia with Ventricular Septal Defect and Systemic-to-Pulmonary Collateral Arteries [fallot Type]
Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, and Right Ventricular Hypertrophy
Ventricular Septal Defect with Obstructed Right Ventricular Outflow
Pulmonary Atresia with Ventricular Septal Defect [fallot Type]
Pulmonary Atresia, Ventricular Septal Defect and Mapcas
Interventricular Septal Defect, in Tetralogy of Fallot
Tof - [tetralogy of Fallot]
Tetrad of Fallot
Fallot Disease
Fallot Complex
Fallot Tetrad
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Basic Information
Medical Symptom
Gene & Mutation
Related Drugs
Disease Model
References Literature
Tetralogy of Fallot, also known as ventricular septal defect with pulmonary stenosis or atresia, dextraposition of aorta, and hypertrophy of right ventricle, is related to congenital heart defects, multiple types, 4 and ventricular septal defect. An important gene associated with Tetralogy of Fallot is JAG1 (Jagged Canonical Notch Ligand 1), and among its related pathways/superpathways are Nervous system development and Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers. The drugs Eplerenone and Antihypertensive Agents have been mentioned in the context of this disorder. Affiliated tissues include heart and trachea, and related phenotypes are abnormal nasal morphology and intrauterine growth retardation
Related ID:
MESH:D013771
ICD11:1408174111

Basic Information

Inheritance
Age of Onset
Prevalence
Related Gene
Related Mouse Models
Reference
MALACARDS
AD
Antenatal
6-9/10000
165
2151
40

Medical Symptom

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Categorization
Description
HPO Frequency
Orphanet Frequency
HPO Source Accession
No data available

Gene & Mutation

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Mutations
No data available

Related Drugs

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No data available

Disease Model

Category
Name
MGI
Related Gene
Strain of Origin
Publications
No data available

References Literature

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PMID
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IF
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