Teeth Hard Tissue Disease is related to dentin dysplasia and dental caries. An important gene associated with Teeth Hard Tissue Disease is ESR2 (Estrogen Receptor 2), and among its related pathways/superpathways are Breast cancer pathway and Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). Related phenotypes are growth/size/body region and homeostasis/metabolism