Trichodentoosseous Syndrome (TDO)

Trichodentoosseous Syndrome, also known as tricho-dento-osseous syndrome, is related to brittle bone disorder and amelogenesis imperfecta, type ie. An important gene associated with Trichodentoosseous Syndrome is DLX3 (Distal-Less Homeobox 3), and among its related pathways/superpathways are Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) and Validated transcriptional targets of deltaNp63 isoforms. Affiliated tissues include bone and skin, and related phenotypes are frontal bossing and widely spaced teeth