Tracheopathia Osteoplastica, also known as tracheobronchopathia osteochondroplastica, is related to spastic paraplegia, ataxia, and mental retardation and silicosis. An important gene associated with Tracheopathia Osteoplastica is TPO (Thyroid Peroxidase). Affiliated tissues include trachea and bone, and related phenotypes are productive cough and tracheal calcification