Thyroid Hormone Metabolism, Abnormal, 1, also known as thyroid hormone metabolism, abnormal, is related to hemimelia and thyroid hormone metabolism, abnormal, 2. An important gene associated with Thyroid Hormone Metabolism, Abnormal, 1 is SECISBP2 (SECIS Binding Protein 2). Affiliated tissues include thyroid, and related phenotypes are decreased circulating free t3 and elevated circulating thyroid-stimulating hormone concentration