Thrombophilia, Familial, Due to Decreased Release of Tissue Plasminogen Activator, also known as thrombophilia 9 due to decreased release of tissue plasminogen, is related to thrombophilia due to decreased release of plat. An important gene associated with Thrombophilia, Familial, Due to Decreased Release of Tissue Plasminogen Activator is PLAT (Plasminogen Activator, Tissue Type). Affiliated tissues include bone marrow and bone.