Three M Syndrome 1 (3M1)

Three M Syndrome 1, also known as 3-m syndrome, is related to isolated growth hormone deficiency, type ia and insulin-like growth factor i, and has symptoms including back pain, muscle cramp and sciatica. An important gene associated with Three M Syndrome 1 is CUL7 (Cullin 7), and among its related pathways/superpathways are Metabolism of proteins and Class I MHC mediated antigen processing and presentation. The drugs Anastrozole and Letrozole have been mentioned in the context of this disorder. Affiliated tissues include bone and brain, and related phenotypes are frontal bossing and short neck