Thrombophilia, also known as hypercoagulability state, is related to prothrombin thrombophilia and heparin cofactor ii deficiency. An important gene associated with Thrombophilia is F5 (Coagulation Factor V), and among its related pathways/superpathways are Metabolism of proteins and Response to elevated platelet cytosolic Ca2+. The drugs Acetylsalicylic acid and Iron have been mentioned in the context of this disorder. Affiliated tissues include liver and whole blood, and related phenotypes are homeostasis/metabolism and nervous system