Thiamine Deficiency Disease, also known as thiamine deficiency, is related to dry beriberi and lactic acidosis. An important gene associated with Thiamine Deficiency Disease is TKT (Transketolase), and among its related pathways/superpathways are Metabolism and Metabolism of water-soluble vitamins and cofactors. The drugs Trimethoprim and Metformin have been mentioned in the context of this disorder. Affiliated tissues include heart and brain, and related phenotypes are growth/size/body region and mortality/aging