Tick-Borne Relapsing Fever, also known as relapsing fever, tick-borne, is related to tick infestation and lyme disease, and has symptoms including tachypnea, tachycardia and hepatosplenomegaly. An important gene associated with Tick-Borne Relapsing Fever is ERVFRD-1 (Endogenous Retrovirus Group FRD Member 1, Envelope), and among its related pathways/superpathways are Complement cascade and Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). The drugs Doxycycline and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include bone marrow and bone, and related phenotypes are Increased shRNA abundance (Z-score > 2) and growth/size/body region