Systemic-Onset Juvenile Idiopathic Arthritis, also known as systemic-onset jia, is related to juvenile rheumatoid arthritis and familial mediterranean fever. An important gene associated with Systemic-Onset Juvenile Idiopathic Arthritis is LACC1 (Laccase Domain Containing 1), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Primary ovarian insufficiency. The drugs Interleukin 1 Receptor Antagonist Protein and Antirheumatic Agents have been mentioned in the context of this disorder. Affiliated tissues include bone and t cells, and related phenotypes are fever and autoimmunity