Systemic Scleroderma

Systemic Scleroderma, also known as scleroderma, is related to scleroderma, familial progressive and limited scleroderma, and has symptoms including exanthema, pruritus and hidebound skin. An important gene associated with Systemic Scleroderma is TSIX (TSIX Transcript, XIST Antisense RNA), and among its related pathways/superpathways are Complement cascade and Senescence and autophagy in cancer. The drugs Ambrisentan and Tadalafil have been mentioned in the context of this disorder. Affiliated tissues include skin and lung, and related phenotypes are homeostasis/metabolism and cardiovascular system