Systemic Mastocytosis

Systemic Mastocytosis, also known as systemic tissue mast cell disease, is related to systemic mastocytosis with associated hematologic neoplasm and indolent systemic mastocytosis. An important gene associated with Systemic Mastocytosis is KIT (KIT Proto-Oncogene, Receptor Tyrosine Kinase), and among its related pathways/superpathways are Innate Immune System and Infectious disease. The drugs Imatinib Mesylate and Cladribine have been mentioned in the context of this disorder. Affiliated tissues include bone marrow and bone, and related phenotypes are Decreased viability and Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435)