Syphilis, also known as chancre, is related to congenital syphilis and secondary syphilis, and has symptoms including syphilitic chancre, fever and pelvic pain. An important gene associated with Syphilis is APOH (Apolipoprotein H), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. The drugs Racivir and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include skin and heart, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and homeostasis/metabolism