Severe Covid-19, also known as susceptibility to severe covid-19, is related to non-severe covid-19 and adult respiratory distress syndrome. An important gene associated with Severe Covid-19 is IFNA2 (Interferon Alpha 2), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Interferon beta-1a and Lopinavir have been mentioned in the context of this disorder. Affiliated tissues include lung and t cells, and related phenotypes are homeostasis/metabolism and immune system