Severe Cutaneous Adverse Reaction, also known as stevens-johnson syndrome, is related to sjogren syndrome and dry eye syndrome. An important gene associated with Severe Cutaneous Adverse Reaction is HLA-B (Major Histocompatibility Complex, Class I, B), and among its related pathways/superpathways are NF-kappaB Signaling and Apoptosis and Autophagy. The drugs Lenograstim and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include skin and eye, and related phenotypes are nausea and vomiting and dysphagia