Severe Pre-Eclampsia, also known as severe preeclampsia, is related to antiphospholipid syndrome and eclampsia, and has symptoms including at least one of the following An important gene associated with Severe Pre-Eclampsia is HLA-G (Major Histocompatibility Complex, Class I, G), and among its related pathways/superpathways are Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) and Adipogenesis. The drugs Methyldopa and Furosemide have been mentioned in the context of this disorder. Affiliated tissues include liver and placenta, and related phenotypes are homeostasis/metabolism and growth/size/body region