Severe Nonproliferative Diabetic Retinopathy, also known as high risk non proliferative diabetic retinopathy, is related to microvascular complications of diabetes 5 and diabetic macular edema. An important gene associated with Severe Nonproliferative Diabetic Retinopathy is INS (Insulin), and among its related pathways/superpathways are Signal Transduction and TGF-Beta Pathway. The drugs Aflibercept and D-Tyrosine have been mentioned in the context of this disorder. Affiliated tissues include eye and retina, and related phenotypes are homeostasis/metabolism and growth/size/body region