Striate Palmoplantar Keratoderma, also known as keratosis palmoplantaris varians of wachters, is related to palmoplantar keratosis and skin disease. An important gene associated with Striate Palmoplantar Keratoderma is DSG1 (Desmoglein 1), and among its related pathways/superpathways are COPI-independent Golgi-to-ER retrograde traffic and Keratinization. Affiliated tissues include skin, and related phenotypes are palmoplantar keratoderma and abnormality of the nail