Spotted Fever, also known as tick typhus due to rickettsia rickettsii, is related to far eastern spotted fever and japanese spotted fever. An important gene associated with Spotted Fever is HTRA1 (HtrA Serine Peptidase 1), and among its related pathways/superpathways are Thermogenesis and Gastrin signaling pathway. The drugs Azithromycin and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include endothelial and skin, and related phenotypes are cardiovascular system and mortality/aging