Spastic Paraplegia 79b, Autosomal Recessive (SPG79B)

Spastic Paraplegia 79b, Autosomal Recessive, also known as early-onset progressive neurodegeneration-blindness-ataxia-spasticity syndrome, is related to spastic paraplegia 34, x-linked and hereditary spastic paraplegia 23, and has symptoms including cerebellar ataxia, muscular fasciculation and quadriparesis. An important gene associated with Spastic Paraplegia 79b, Autosomal Recessive is UCHL1 (Ubiquitin C-Terminal Hydrolase L1), and among its related pathways/superpathways is Alpha-synuclein signaling. Affiliated tissues include eye and brain, and related phenotypes are hyperreflexia and ataxia