Spastic Paraplegia 85, Autosomal Recessive, also known as spg85, is related to spastic paraplegia 83, autosomal recessive and spastic paraplegia 86, autosomal recessive. An important gene associated with Spastic Paraplegia 85, Autosomal Recessive is RNF170 (Ring Finger Protein 170), and among its related pathways/superpathways are Integrated breast cancer pathway and Transcriptional Regulation by E2F6. Affiliated tissues include brain, and related phenotypes are optic atrophy and lower limb spasticity