Spastic Ataxia 8

Spastic Ataxia 8 is related to spastic ataxia 8, autosomal recessive, with hypomyelinating leukodystrophy and spastic ataxia. An important gene associated with Spastic Ataxia 8 is NKX6-2 (NK6 Homeobox 2), and among its related pathways/superpathways are Primary ovarian insufficiency and Translation factors. Related phenotypes are Decreased NANOG protein expression and Increased shRNA abundance (Z-score > 2)